The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Nouvelle définition 2016 du sepsis et du choc septique. ces nouvelles définitions ont été validées par l'European Society of Intensive Care Medicine et la Society of Critical Care Medicine

Recommendations Sepsis should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. For clinical operationalization, organ dysfunction can be represented by an increase in the Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score of 2 points or more, which is associated with an in-hospital mortality greater than 10%. Septic shock should be defined as a subset of sepsis in which particularly profound circulatory, cellular, and metabolic abnormalities are associated with a greater risk of mortality than with sepsis alone. Patients with septic shock can be clinically identified by a vasopressor requirement to maintain a mean arterial pressure of 65 mm Hg or greater and serum lactate level greater than 2 mmol/L (>18 mg/dL) in the absence of hypovolemia. This combination is associated with hospital mortality rates greater than 40%. In out-of-hospital, emergency department, or general hospital ward settings, adult patients with suspected infection can be rapidly identified as being more likely to have poor outcomes typical of sepsis if they have at least 2 of the following clinical criteria that together constitute a new bedside clinical score termed quickSOFA (qSOFA): respiratory rate of 22/min or greater, altered mentation, or systolic blood pressure of 100 mm Hg or less.

Le texte est en libre accés ici : JAMA. 2016;315(8):801-810. doi:10.1001/jama.2016.0287.

Lisez ceci des commentaires ici : Sepsis-3 : Le nouveau visage du sepsis et du choc septique